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Studies and trials

Our research team support over 70 studies within Evelina London.

Our research includes studies of new medicines and devices (known as clinical trials) as well of studies that observe (watch) how children grow and learn.

Some of the studies currently running at Evelina London are listed below. 

How to get involved

If you are interested in taking part in a research study as a patient, please speak to your doctor who will refer you to the appropriate study team.

Our studies

The Cleft Collective Cohort studies

Investigator: Emma Southby, cleft lip and palate matron
Contact: Vania Oliveira and Amanpreet Banga, research nurses
t: 020 7188 7188 extension 52237.

Why is the study running/who is running the study?

The cleft study is run with our cleft lip and palate service. It looks at children born with cleft (split) lip or palate and aims to understand why it happens, how it affects the child’s life and how children with cleft can be better supported throughout their life.

What is it trying to achieve?

Cleft lip/palate is a congenital condition, which means that it is passed down (inherited) from the child’s parents.

Even though cleft is passed through a family, not everyone in the family will be born with a cleft lip or palate. In order to understand why this happens to some family members and not to others, the cleft study looks at the environment the family lives in and their DNA to see if there is any reason why some family members have cleft and some do not.

What does the study involve?

DNA is taken from saliva (spit), blood and tissue (muscle) samples from cleft children, their parents and their siblings.

What is the study's goal?

The study’s goal is to create a group (cohort) of children with cleft who can be followed until they reach 15 years of age so that we can build a better understanding of how having a cleft lip/palate effects their learning and development.

The study hopes to find a pattern (trend) that can be used to create better services and support for children born with cleft lip/palate

How can I get involved?

If you are interested in your child taking part in this research study as a patient, please speak to your doctor who will refer you to the appropriate study team.

The HOT-KID study – chronic kidney disease

Investigator: Dr Manish Sinha
Contact: Humra Chadwick, clinical trial coordinator
Tel: 020 7188 7188, extension 53824

Why is the study running/ Who is running the study?

The HOT-KID study is run with our renal (kidney) and urology department. The study looks at children with chronic kidney disease (CKD) and the related health issues (comorbidities) they experience as young adults.

What is it trying to achieve?

The study focuses on one of the health related issues - heart disease.

The study is made up of two parts. Firstly, it looks at hundreds of children with CKD to understand the shape and size of their hearts and how their hearts work.

Secondly, it compares two approaches to lowering children’s blood pressure with the aim of reducing the number of children developing heart disease as they grow older. 

How can I get involved?

If you are interested in your child taking part in this research study as a patient, please speak to your doctor who will refer you to the appropriate study team.

NEUCHILD (Neurim) – neurodevelopmental disabilities sleep study 

Investigator: Professor Paul Gringras
Contact: Stanislava Cantwell, research nurse
Tel: 020 7188 7188, extension 52237

Why is the study running/who is running the study?

The NEUCHILD study is run with our Sleep Centre and neurology department. The study is designed to investigate how safe and how effective the medicine known as Circadin® is for children with neurodevelopmental disabilities who sleep badly.

What is it trying to achieve/find out?

It is hoped that children who receive Circadin® will sleep longer without waking up and experience a better quality of sleep

How can I get involved?

If you are interested in your child taking part in this research study as a patient, please speak to your doctor who will refer you to the appropriate study team.

UK ChiMES – meningitis and encephalitis

Investigator: Dr Esse Menson
Contact: Elisabeth Reus, research matron
Tel: 020 7188 7188, extension 54283

Why is the study running/who is running the study?

The ChiMES study is run with our infectious disease department. The study’s goal is to better understand what causes meningitis and encephalitis and what happens to people who get (contract) the diseases.

What does the study involve?

Samples are taken from hundreds of children with the diseases.

These samples are tested and the results compared to what happens to the children after they leave hospital.

What is the study’s goal?

The aim of the study is to design a tool that will help doctors to identify these diseases earlier and treat them better.

How can I get involved?

If you are interested in your child taking part in this research study as a patient, please speak to your doctor who will refer you to the appropriate study team.

 FibCon – heart services

Investigator: Dr Shane Tibby
Contact: Julia Harris, senior research nurse
Tel: 020 7188 7188, extension 51548

Why is the study running/who is running the study?

The Fibcon study is run with our heart services (cardiac surgery team) and the intensive care unit (PICU).

The study focuses on children undergoing heart surgery whose blood does not thicken (clot) as it should.

What does the study involve?

This study provides children with a dose of fibrinogen concentrate during their surgery.

The concentrated substance allows the child’s blood to clot and stops them from bleeding in an uncontrollable way.

What is the study’s goal?

By preventing the children from bleeding during, and immediately after their surgery, it is hoped that they will recover quicker and be healthier after their surgery.

How can I get involved?

If you are interested in your child taking part in this research study as a patient, please speak to your doctor who will refer you to the appropriate study team.

The GWSP08258 spasticity study

Investigator: Dr Charlie Fairhurst
Contact: Liz Moore, research nurse
Te: 020 7188 7188, extension 52237

Why is the study running/who is running the study?

This study is run with our neurology department.

What is it trying to achieve/find out?

The study looks at how the drug Sativex®, compared to a placebo, has an effect in spasticity, sleep quality, pain, quality of life (of both the child and the parent/caregiver), comfort and depression.

What is the study’s goal?

The aim of the study is to answer whether Sativex® works and if it is safe in this particular patient group.

The study also aims to look at whether the drug improves patients' lives and can be used instead of medications with more severe side effects or more invasive treatments.

How can I get involved?

If you are interested in your child taking part in this research study as a patient, please speak to your doctor who will refer you to the appropriate study team.


Contacts

If you would like to find out about what other research is happening at Eveliina London please email: evelinaresearch@gstt.nhs.uk
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